Role of serum tumor markers in monitoring for recurrence of gastric cancer following radical gastrectomy

It has been suggested that the serum tumor markers AFP, CEA, and CA19-9 may serve as prognostic factors or indicators for recurrence after radical gastrectomy for gastric cancer. We compared the value of these markers in a group with (n=52) and a group without recurrent gastric cancer (n=52) accordi...

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Bibliographic Details
Published in:Digestive diseases and sciences 2006-11, Vol.51 (11), p.2081-2086
Main Authors: SEOK REYOL CHOI, JIN SEOK JANG, JONG HUN LEE, MYUNG HWAN ROH, MIN CHAN KIM, WON SUP LEE, QURESHI, Waqar
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
CA-19-9 Antigen - blood
Female
Gastrectomy
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Monitoring, Physiologic
Neoplasm Invasiveness
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - diagnosis
Peritoneal Neoplasms - blood
Peritoneal Neoplasms - diagnosis
Predictive Value of Tests
Stomach Neoplasms - diagnosis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach, duodenum, intestine, rectum, anus
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tumors
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Summary:It has been suggested that the serum tumor markers AFP, CEA, and CA19-9 may serve as prognostic factors or indicators for recurrence after radical gastrectomy for gastric cancer. We compared the value of these markers in a group with (n=52) and a group without recurrent gastric cancer (n=52) according to the site of recurrence. Serum levels of tumor markers were measured at the time of preoperative diagnosis and at follow-up. At least one tumor marker was positive preoperatively in 20 with recurrence vs. 7 controls (p=0.007). The peritoneum was the most common recurrent site. The positive predictive value of AFP was high at the time of diagnosis and CA19-9 positivity was high at the time of recurrence. Positive CEA suggested recurrence to the liver. In summary, an elevated tumor marker at diagnosis or during follow up may identify patients at higher risk for a recurrence. CA19-9 may be especially useful as a marker for peritoneal recurrence of the gastric cancer, and CEA for recurrence to liver.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-9166-5