Nephroureterectomy for treating upper urinary tract transitional cell carcinoma: time to change the treatment paradigm?

OBJECTIVE To evaluate factors associated with disease recurrence and survival in patients undergoing nephroureterectomy for upper urinary tract transitional cell carcinoma (UUT‐TCC) in one centre over an 18‐year period. PATIENTS AND METHODS The records of patients who had a nephroureterectomy for UU...

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Bibliographic Details
Published in:BJU international 2006-12, Vol.98 (6), p.1176-1180
Main Authors: Brown, Gordon A., Busby, J. Erik, Wood, Christopher G., Pisters, Louis L., Dinney, Colin P.N., Swanson, David A., Grossman, H. Barton, Pettaway, Curtis A., Munsell, Mark F., Kamat, Ashish M., Matin, Surena F.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - surgery
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Humans
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoadjuvant Therapy - methods
Neoplasm Recurrence, Local - surgery
Neoplasm Staging - methods
Nephrectomy - methods
Nephrology. Urinary tract diseases
nephroureterectomy
outcome
Prognosis
renal pelvis
surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
survival
TCC
Treatment Outcome
Tumors of the urinary system
ureter
Ureter - surgery
Ureteral Neoplasms - mortality
Ureteral Neoplasms - surgery
Urinary tract. Prostate gland
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Summary:OBJECTIVE To evaluate factors associated with disease recurrence and survival in patients undergoing nephroureterectomy for upper urinary tract transitional cell carcinoma (UUT‐TCC) in one centre over an 18‐year period. PATIENTS AND METHODS The records of patients who had a nephroureterectomy for UUT‐TCC at our institution from 1986 to 2004 were reviewed for clinical, pathological and treatment period data. Cox’s proportional hazards regression model was used to test the statistical significance of several potential prognostic factors for recurrence and survival. RESULTS The median overall duration of follow‐up was 2.5 years for 184 patients. Significant prognosticators for disease‐specific survival (DSS) by univariate analysis were tumour stage (P 
ISSN:1464-4096
1464-410X
DOI:10.1111/j.1464-410X.2006.06524.x