Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack

It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA. Of these, 1...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2007-08, Vol.116 (8), p.928-935
Main Authors: SEN, Souvik, HINDERLITER, Alan, SEN, Pranab K, SIMMONS, Jennifer, BECK, James, OFFENBACHER, Steven, MAGNUS OHMAN, E, OPPENHEIMER, Stephen M
Format: Article
Language:English
Subjects:
Aged
Aorta, Thoracic - pathology
Atherosclerosis - diagnostic imaging
Atherosclerosis - epidemiology
Atherosclerosis - pathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Disease Progression
Disease-Free Survival
Diseases of the aorta
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Echocardiography, Transesophageal
Female
Follow-Up Studies
Homocysteine - blood
Humans
Hypertension - epidemiology
Ischemic Attack, Transient - epidemiology
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Neurology
Prevalence
Recurrence
Risk Factors
Stroke - epidemiology
Vascular diseases and vascular malformations of the nervous system
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Summary:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA. Of these, 125 consented to a follow-up transesophageal echocardiogram at 12 months. Adequate paired AA images were obtained in 117 (78 with strokes, 39 with TIAs), which allowed detailed measurements of plaques. On admission for their index stroke or TIA, patients were assessed for stroke risk factors, stroke subtypes, baseline AA plaque characteristics, and laboratory parameters. Progression of AA atheroma was observed in 33 patients (28%) on 12-month follow-up transesophageal echocardiogram. It was determined that the progression group had significantly higher adjusted homocysteine levels (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.106.671727