Role of Matrix metalloproteinase-7 in colorectal adenomas

Matrix metalloproteinases (MMPs) degregade and remodel the extracellular matrix. They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas. In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas. Alt...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2006-11, Vol.51 (11), p.2068-2072
Main Authors: KIRIMLIOGLU, Hale, KIRIMLIOGLU, Vedat, YILMAZ, Sezai, SAGIR, Vedat, COBAN, Sacit, TURKMEN, Emine, HILMIOGLU, Fatih
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Adenoma - pathology
Adenoma, Villous - enzymology
Adenoma, Villous - pathology
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - pathology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunohistochemistry
Male
Matrix Metalloproteinase 7 - metabolism
Matrix Metalloproteinase 7 - physiology
Middle Aged
Prospective Studies
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Matrix metalloproteinases (MMPs) degregade and remodel the extracellular matrix. They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas. In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas. Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date. Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma. MMP-7 expression was classified into three categories, as negative, weakly stained, or strongly stained, depending on the percentage of cells stained. Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3. Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas. G0 and G1 staining was not detected in the villous adenomas. The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different. In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-005-9070-4