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Apolipoprotein E Polymorphism Influences Lipid Phenotypes in Chinese Families With Familial Combined Hyperlipidemia

Background Apolipoprotein E (apoE) polymorphism is associated with changes in the lipoprotein profile of individuals with familial combined hyperlipidemia (FCHL), but its effects on the lipoprotein profiles of members of Chinese families with FCHL remain uncertain. Methods and Results 43 FCHL famili...

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Published in:Circulation Journal 2006, Vol.70(12), pp.1606-1610
Main Authors: Pei, Wei-Dong, Zhang, Yan-Hong, Sun, Yu-Hua, Gu, Yu-Chun, Wang, Yan-Fen, Zhang, Chao-Yang, Zhang, Jian, Liu, Li-Sheng, Hui, Ru-Tai, Liu, Yu-Qing, Yang, Yue-Jin
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Language:English
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Summary:Background Apolipoprotein E (apoE) polymorphism is associated with changes in the lipoprotein profile of individuals with familial combined hyperlipidemia (FCHL), but its effects on the lipoprotein profiles of members of Chinese families with FCHL remain uncertain. Methods and Results 43 FCHL families (n=449) and 9 normolipidemic families (n=73) were recruited to assess the influence of apoE polymorphism on plasma lipids. The relative frequency of the ε4 allele in affected and unaffected FCHL relatives, spouses and normolipidemic members was 13.8%, 5.3%, 9.1% and 6.8%, respectively, with a significantly higher frequency in affected FCHL relatives, compared with unaffected FCHL relatives or normolipidemic members (p=0.0002 or p=0.029). In FCHL relatives, the apoE4 subset (E4/4 and E4/3) exhibited significantly higher levels of apoB, total cholesterol and low-density lipoprotein-cholesterol (LDL-C) than did the apoE3 (E3/3) subset, especially in women (all p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.1606