Glucocorticoid resistance

Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic con...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2006-10, Vol.71 (10), p.1073-1081
Main Author: Orbak, Z
Format: Article
Language:English
Subjects:
Animals
Drug Resistance
Genes
Glucocorticoids - metabolism
Glucocorticoids - pharmacology
Glucocorticoids - physiology
Humans
Mutation
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - metabolism
Receptors, Glucocorticoid - physiology
Signal Transduction
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Summary:Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ insensitivity to glucocorticoids. The molecular basis of glucocorticoid resistance in several families and sporadic cases has been ascribed to mutations in the human glucocorticoid receptor alpha (hGRalpha) gene, which impair the ability of the receptor to transduce the glucocorticoid signal. Glucocorticoids are crucial for life, and therefore complete glucocorticoid resistance is uncommon. The purpose of this review is to discuss the many structural and functional features of the glucocorticoid receptor and also to evaluate the main clinical and laboratory characteristics of cortisol resistance.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297906100038