Neurons in motion: same principles for different shapes?

The special conformation of the developing nervous system, in which progenitor zones are largely confined to the lumen of the neural tube, places neuronal migration as one of the most fundamental processes in brain development. Previous studies have shown that different neuronal types adopt distinct...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2006-12, Vol.29 (12), p.655-661
Main Authors: Marín, Oscar, Valdeolmillos, Miguel, Moya, Fernando
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - cytology
Brain - embryology
Cell adhesion & migration
Cell Movement - physiology
Cell Shape - physiology
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Humans
Neurons
Neurons - cytology
Neurons - physiology
Neurosciences
Perception
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Studies
Vertebrates: nervous system and sense organs
Vision
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Summary:The special conformation of the developing nervous system, in which progenitor zones are largely confined to the lumen of the neural tube, places neuronal migration as one of the most fundamental processes in brain development. Previous studies have shown that different neuronal types adopt distinct morphological modes of migration in the developing brain, indicating that neuronal migration might be a diverse process. Here, we review recent data on the molecular mechanisms underlying neuronal migration that suggest that similar signaling principles are responsible for the frequently variable morphology of different types of migrating neuron. According to this idea, the same basic molecular mechanisms found in other cell types, such as fibroblasts, might have been adapted to the special morphological needs of migrating neurons in different regions of the developing brain.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2006.10.001