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CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia

Mutations in the CHMP2B gene have been recently identified in a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). We report the frequency of CHMP2B mutations in 162 FTD patients recruited from a large population‐based study of FTD carried out...

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Published in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-12, Vol.141B (8), p.944-946
Main Authors:	Rizzu, Patrizia, van Mil, Saskia E., Anar, Burcu, Rosso, Sonia M., Kaat, Laura Donker, Heutink, Peter, van Swieten, John C.
Format:	Article
Language:	English
Subjects:	Adult and adolescent clinical studies Biological and medical sciences CHMP2B Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - genetics DNA Mutational Analysis Endosomal Sorting Complexes Required for Transport Female frontotemporal dementia Gene Frequency Humans Male MAPT Medical sciences Middle Aged Mutation - genetics mutation frequency Nerve Tissue Proteins - genetics Netherlands Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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container_title	American journal of medical genetics. Part B, Neuropsychiatric genetics
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creator	Rizzu, Patrizia van Mil, Saskia E. Anar, Burcu Rosso, Sonia M. Kaat, Laura Donker Heutink, Peter van Swieten, John C.
description	Mutations in the CHMP2B gene have been recently identified in a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). We report the frequency of CHMP2B mutations in 162 FTD patients recruited from a large population‐based study of FTD carried out in The Netherlands. Our results suggest that mutations in CHMP2B are a rare cause of FTD as compared to MAPT mutations. © 2006 Wiley‐Liss, Inc.
doi_str_mv	10.1002/ajmg.b.30410
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Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Mutations in the CHMP2B gene have been recently identified in a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). We report the frequency of CHMP2B mutations in 162 FTD patients recruited from a large population‐based study of FTD carried out in The Netherlands. Our results suggest that mutations in CHMP2B are a rare cause of FTD as compared to MAPT mutations. © 2006 Wiley‐Liss, Inc.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>CHMP2B</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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subjects	Adult and adolescent clinical studies Biological and medical sciences CHMP2B Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - genetics DNA Mutational Analysis Endosomal Sorting Complexes Required for Transport Female frontotemporal dementia Gene Frequency Humans Male MAPT Medical sciences Middle Aged Mutation - genetics mutation frequency Nerve Tissue Proteins - genetics Netherlands Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
title	CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia
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