Synthesis of fluorescent and photoaffinity-labeled derivatives of bisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin

The synthesis of bisphenol A derivatives which have a fluorescent dye and a photo-reactive group and their biological evaluation are reported. Bisphenol A derivatives, possessing a fluorescent dye and a photo-reactive group, were synthesized from bisphenol A, and the inhibitory activity of the deriv...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-09, Vol.17 (18), p.5121-5124
Main Authors: Maezawa, Nobuhiro, Tsuchikawa, Hiroshi, Katsumura, Shigeo, Kubo, Tomoko, Imaoka, Susumu
Format: Article
Language:English
Subjects:
Benzhydryl Compounds
Biological and medical sciences
Bisphenol A
Cell Hypoxia
Chemical and industrial products toxicology. Toxic occupational diseases
Erythropoietin - metabolism
Fluorescence
Fluorescent Dyes - chemical synthesis
Humans
Inhibition
Medical sciences
Phenols - chemistry
Photoaffinity Labels - chemical synthesis
Photoaffinity-label
Synthesis
Toxicology
Various organic compounds
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Summary:The synthesis of bisphenol A derivatives which have a fluorescent dye and a photo-reactive group and their biological evaluation are reported. Bisphenol A derivatives, possessing a fluorescent dye and a photo-reactive group, were synthesized from bisphenol A, and the inhibitory activity of the derivatives was evaluated against hypoxic response. The synthesized derivatives were found to inhibit the hypoxic expression of erythropoietin in Hep3B cells as well as bisphenol A.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.07.007