Epidemiology of Staphylococcal Resistance

An understanding of the prevalence of resistant Staphylococcus aureus and the risk factors for infection with resistant isolates is essential to help clinicians choose appropriate antibiotic therapy. Selection pressure due to prior and inappropriate antibiotic use of any kind seems to be the main dr...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2007-09, Vol.45 (Supplement-3), p.S171-S176
Main Author: Shorr, Andrew F.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobials
Bacteremia
Drug resistance
Epidemiology
Humans
Infections
Infectious diseases
Methicillin Resistance
Microbial sensitivity tests
Mortality
Pathogens
Risk Factors
Selection, Genetic
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An understanding of the prevalence of resistant Staphylococcus aureus and the risk factors for infection with resistant isolates is essential to help clinicians choose appropriate antibiotic therapy. Selection pressure due to prior and inappropriate antibiotic use of any kind seems to be the main driving force behind the increasing rates of multidrug resistance in methicillin-resistant S. aureus (MRSA) strains. Resistance to glycopeptide antibiotics in MRSA has also emerged in recent years, along with increased use of vancomycin to treat serious infections due to MRSA. Infections due to MRSA are associated with significantly increased morbidity, mortality, length of hospital stay, and costs, compared with infections due to methicillin-susceptible S. aureus, despite adjustment for disease severity and initially appropriate antibiotic treatment. Improvements in the preparation and dissemination of antibiograms, along with adequate public reporting of MRSA trends, are needed to address the challenge of choosing appropriate initial antibiotic treatment for MRSA infections.
ISSN:1058-4838
1537-6591
DOI:10.1086/519473