Inflammatory syndrome in patients on hemodialysis

Mortality is markedly elevated in hemodialysis (HD) patients. Between 30 and 50% of prevalent patients have elevated serum levels of inflammatory markers such as C-reactive protein and IL-6. The presence of inflammation, chronic or episodic, has been found to be associated with increased mortality r...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2006-12, Vol.17 (12 Suppl 3), p.S274-S280
Main Authors: JOFRE, Rosa, RODRIGUEZ-BENITEZ, Patrocinio, LOPEZ-GOMEZ, Juan M, PEREZ-GARCIA, Rafael
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Emergency and intensive care: renal failure. Dialysis management
Humans
Inflammation - etiology
Inflammation - prevention & control
Intensive care medicine
Kidney Failure, Chronic - therapy
Medical sciences
Nephrology. Urinary tract diseases
Renal Dialysis - adverse effects
Risk Factors
Syndrome
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Summary:Mortality is markedly elevated in hemodialysis (HD) patients. Between 30 and 50% of prevalent patients have elevated serum levels of inflammatory markers such as C-reactive protein and IL-6. The presence of inflammation, chronic or episodic, has been found to be associated with increased mortality risk. The causes of inflammation are multifactorial and include patient-related factors, such as underlying disease, comorbidity, oxidative stress, infections, obesity, and genetic or immunologic factors, or on the other side, HD-related factors, mainly depending on the membrane biocompatibility and dialysate quality. The adequate knowledge of these causes and their prevention or treatment if possible may contribute to improving the inflammatory state of patients who are on HD and possibly their mortality.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2006080926