The evaluation of genetic tests

Scientific advances in genetics and molecular biology have been very successful in advancing our knowledge of biological mechanisms in health and disease, and in catalysing a variety of technological innovations. The number of genetic tests available has consequently increased exponentially over the...

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Bibliographic Details
Published in:Journal of public health (Oxford, England) England), 2007-09, Vol.29 (3), p.246-250
Main Authors: Zimmern, Ron L., Kroese, Mark
Format: Article
Language:English
Subjects:
biomarker
Evaluation
Frameworks
Genetic Markers
Genetic Predisposition to Disease
Genetic screening
genetic test
Genetic Testing - ethics
Genetic Testing - legislation & jurisprudence
Genetic Testing - standards
Genetics - trends
Health improvement
Humans
Marketing
Molecular Biology - trends
Predictive Value of Tests
Public health
Public Health - trends
Reproducibility of Results
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Summary:Scientific advances in genetics and molecular biology have been very successful in advancing our knowledge of biological mechanisms in health and disease, and in catalysing a variety of technological innovations. The number of genetic tests available has consequently increased exponentially over the last few years. Their development has not been accompanied by processes and systems to evaluate these tests in a proper and formal manner to establish their clinical validity and utility. A framework for the evaluation of genetic tests has been developed. This paper reviews the current practice of genetic test evaluation, highlighting the limitations and future challenges in this area of public health.
ISSN:1741-3842
1741-3850
DOI:10.1093/pubmed/fdm028