Cytologic features of müllerian papilloma of the cervix: Mimic of malignancy

Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children. The cytologic features of benign müllerian papilloma have never been described. We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma f...

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Bibliographic Details
Published in:Diagnostic cytopathology 2007-09, Vol.35 (9), p.607-611
Main Authors: Hollowell, Monica L., Goulart, Robert A., Gang, David L., Otis, Christopher N., Prior, Jeffrey, Sachs, Barry F., Pantanowitz, Liron
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
cervix
cytology
Diagnosis, Differential
Female
Humans
Infant
müllerian
papilloma
Papilloma - diagnosis
Papilloma - pathology
Rhabdomyosarcoma, Embryonal - diagnosis
Rhabdomyosarcoma, Embryonal - pathology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - pathology
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Summary:Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children. The cytologic features of benign müllerian papilloma have never been described. We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma from the vaginal fluid specimen of a 15‐mo‐old girl using touch prep, ThinPrep™, and cell block preparations. The deceptive cytologic features of a cellular specimen with complex papillary fronds composed of overlapping and crowded small hyperchromatic cells, with a high nuclear:cytoplasmic ratio, and feathering in this case resembled a malignant neoplasm. The clinical findings and cytomorphology of a benign müllerian papilloma can mimic those of malignant lesions of the female lower genital tract such as sarcoma botryoides and adenocarcinoma. An awareness of this entity and its potential to mimic these more aggressive neoplasms is essential for accurate diagnosis and to avoid over‐treatment. Diagn. Cytopathol. 2007;35:607‐611. © 2007 Wiley‐Liss, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.20712