Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats

Using conflict drinking and forced swimming tests in rats, we examined the anxiolytic- and the antidepressant-like activity, respectively, of (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB 269970), a selective 5-HT(7) receptor antagonist, after its intrahippoc...

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Bibliographic Details
Published in:European journal of pharmacology 2006-12, Vol.553 (1-3), p.185-190
Main Authors: WESOŁOWSKA, Anna, NIKIFORUK, Agnieszka, STACHOWICZ, Katarzyna
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents
Antidepressive Agents
Antidepressive Agents, Tricyclic - pharmacology
Biological and medical sciences
Conflict (Psychology)
Diazepam - pharmacology
Drinking Behavior - drug effects
Electroshock
Hippocampus - physiology
Imipramine - pharmacology
Male
Medical sciences
Microinjections
Motor Activity - drug effects
Pharmacology. Drug treatments
Phenols - administration & dosage
Phenols - pharmacology
Rats
Rats, Wistar
Receptors, Serotonin - drug effects
Sulfonamides - administration & dosage
Sulfonamides - pharmacology
Swimming - psychology
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Summary:Using conflict drinking and forced swimming tests in rats, we examined the anxiolytic- and the antidepressant-like activity, respectively, of (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB 269970), a selective 5-HT(7) receptor antagonist, after its intrahippocampal administration. SB 269970 at doses of 0.3, 1 and 3 mug showed an anticonflict effect which was weaker than that of diazepam (40 mug), whereas SB 269970 at doses of 3 and 10 mug had marked anti-immobility action comparable to that of imipramine (0.1 mug). Importantly, the anxiolytic- and antidepressant-like activity of SB 269970 seemed to be specific, since that agent - when given by the same route in doses effective in either model - affected neither the shock threshold, nor the non-punished water consumption, nor the exploratory activity of rats. The obtained results indicate that the hippocampus is one of the neuroanatomical structures involved in the potential anxiolytic and, in particular, antidepressant activity of SB 269970.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2006.09.064