Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a review

The immunoprotective properties of bovine milk immunoglobulin G (IgG) have led to a recent proliferation of nutritional products incorporating this protein. It has therefore become critical that reliable analytical techniques for the measurement of the IgG content in such products are available. Thi...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2007-09, Vol.389 (1), p.93-109
Main Authors: Gapper, Leyton W, Copestake, David E. J, Otter, Don E, Indyk, Harvey E
Format: Article
Language:English
Subjects:
Analysis
Animals
cattle
colostrum
Colostrum - chemistry
dietary supplements
Dietary Supplements - analysis
Humans
IgG
immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - immunology
milk
Milk - chemistry
proteins
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Summary:The immunoprotective properties of bovine milk immunoglobulin G (IgG) have led to a recent proliferation of nutritional products incorporating this protein. It has therefore become critical that reliable analytical techniques for the measurement of the IgG content in such products are available. This literature review surveys current methods of analysis for IgG, including separation-based or immuno-based concentration analysis. The review also discusses nutraceutical applications, regulatory issues, stability of IgG and the significance of primary reference material in IgG analysis.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-007-1391-z