Trijugin-Type Limonoids from the Leaves of Cipadessa cinerascens

Four new trijugin-type limonoids, cipatrijugins A−D (1−4), together with the known cipadesin A (5), were isolated from the leaves of Cipadessa cinerascens, and their structures were elucidated on the basis of spectroscopic and computational methods. The ability of compounds 1−5 to inhibit the growth...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-08, Vol.70 (8), p.1352-1355
Main Authors: Di, Ying-Tong, He, Hong-Ping, Liu, Hai-Yang, Yi, Ping, Zhang, Zhen, Ren, Yan-Li, Wang, Jun-Song, Sun, Qian-Yun, Yang, Fu-Mei, Fang, Xin, Li, Shun-Lin, Zhu, Hua-Jie, Hao, Xiao-Jiang
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
cell growth
chemical structure
cipadesin
Cipadessa cinerascens
cipatrijugins
cultured cells
cytotoxicity
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
General pharmacology
Humans
Limonins - chemistry
Limonins - isolation & purification
Limonins - pharmacology
limonoids
Medical sciences
medicinal plants
Meliaceae
Meliaceae - chemistry
Molecular Structure
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
Plant Leaves - chemistry
Plants, Medicinal - chemistry
spectral analysis
stereochemistry
trijugin
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Summary:Four new trijugin-type limonoids, cipatrijugins A−D (1−4), together with the known cipadesin A (5), were isolated from the leaves of Cipadessa cinerascens, and their structures were elucidated on the basis of spectroscopic and computational methods. The ability of compounds 1−5 to inhibit the growth of the A549 and K562 tumor cell lines was evaluated.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0700624