Proteome of mesenchymal stem cells

Proteomics has evolved, in recent years, into effective tools for basic and applied stem cell research, and has been extensively used to facilitate the identification of changes in signal transduction components, especially with regard to plasticity, proliferation, and differentiation. Several recen...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2007-08, Vol.7 (16), p.2881-2894
Main Authors: Park, Hye Won, Shin, Jun-Seop, Kim, Chan-Wha
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Mesenchymal stem cells
Mesenchymal Stromal Cells - metabolism
Miscellaneous
Proteins
Proteins - genetics
Proteins - metabolism
Proteome
RNA, Messenger - genetics
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Summary:Proteomics has evolved, in recent years, into effective tools for basic and applied stem cell research, and has been extensively used to facilitate the identification of changes in signal transduction components, especially with regard to plasticity, proliferation, and differentiation. Several recent reports have also employed proteomic strategies to characterize human mesenchymal stem cells (hMSC) and their differentiated derivatives. Although these approaches have yielded valuable data, the results highlight the fact that only the limited numbers of proteins are characterized at the protein level in these cells, thus necessitating expandable MSC proteome dataset. This review presents, for the first time, an expandable list of MSC proteins, which will function as a starting point for the generation of a comprehensive reference map of their proteome. Also, the better way to bridge current gap between genomics and proteomics study such as integrated proteomic and transcriptomic analyses is discussed.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.200700089