Prevention of Gynaecological Adhesions using Haemostatic Fleece in a Rabbit Model

This pre-clinical study was performed to investigate the ability of the haemostatic fleece TachoComb® to prevent adhesion formation following uterine surgery. Thirty rabbits were randomized to receive TachoComb® or no intervention following incision to the right uterine horn. After 14 days, the anim...

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Bibliographic Details
Published in:Journal of international medical research 2006-09, Vol.34 (5), p.505-513
Main Authors: Dickneite, G, Rolle, U, Rosenthal, D
Format: Article
Language:English
Subjects:
Animals
Aprotinin - therapeutic use
Drug Combinations
Female
Fibrinogen - therapeutic use
Gynecologic Surgical Procedures - adverse effects
Gynecologic Surgical Procedures - methods
Hemostasis, Surgical - methods
Models, Animal
Rabbits
Thrombin - therapeutic use
Tissue Adhesions - prevention & control
Treatment Outcome
Uterus - surgery
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Summary:This pre-clinical study was performed to investigate the ability of the haemostatic fleece TachoComb® to prevent adhesion formation following uterine surgery. Thirty rabbits were randomized to receive TachoComb® or no intervention following incision to the right uterine horn. After 14 days, the animals were killed and examined for the presence of adhesion. The lengths of any adhesions were measured and the severity was recorded as a score (0, no adhesion; 1, adhesion easy to lyse; 2, adhesion lysed with traction; 3, adhesion separated by sharp dissection). The incidence of adhesions was 100% in the control group compared with 33% in the TachoComb®-treated animals. The mean adhesion score was significantly lower (0.7 versus 2.2) and the mean adhesion length category was significantly shorter (0.4 versus 2.0) with TachoComb® than in the control group. This study indicates that TachoComb® is a well-tolerated and effective means of preventing adhesion following gynaecological surgery.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000603400507