Living with p53, Dying of p53

The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate th...

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Bibliographic Details
Published in:Cell 2007-08, Vol.130 (4), p.597-600
Main Authors: Aylon, Yael, Oren, Moshe
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Apoptosis - physiology
Cell Cycle - genetics
Cell Cycle - physiology
Cell Death - genetics
Cell Death - physiology
DNA Damage
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Models, Biological
Neoplasms - genetics
Protein Binding
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
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Summary:The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2007.08.005