Rapid detection of causative pathogen of peritonitis using in-situ hybridization in a patient with continuous ambulatory peritoneal dialysis

Abstract Continuous ambulatory peritoneal dialysis (CAPD) peritonitis is a common problem in patients on peritoneal dialysis, and the bacteriological diagnosis is important for the treatment of this condition. We used Hybrizep (a method for detecting the genes of bacteria ingested in phagocytes), to...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2007-08, Vol.13 (4), p.273-275
Main Authors: Ota, Kyuma, Maruyama, Hiroki, Iino, Noriaki, Nakamura, Gen, Shimotori, Masaaki, Tanabe, Yoshinari, Tsukada, Hiroki, Gejyo, Fumitake
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Female
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization - methods
In-situ hybridization
Middle Aged
Peritoneal dialysis
Peritoneal Dialysis, Continuous Ambulatory - adverse effects
Peritonitis
Peritonitis - diagnosis
Peritonitis - microbiology
Staphylococcal Infections - diagnosis
Staphylococcal Infections - drug therapy
Staphylococcal Infections - genetics
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - genetics
Staphylococcus epidermidis - pathogenicity
Streptococcus
Vancomycin - therapeutic use
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Summary:Abstract Continuous ambulatory peritoneal dialysis (CAPD) peritonitis is a common problem in patients on peritoneal dialysis, and the bacteriological diagnosis is important for the treatment of this condition. We used Hybrizep (a method for detecting the genes of bacteria ingested in phagocytes), to detect the causative bacterium in a 50-year-old woman receiving peritoneal dialysis who was admitted our hospital with bacterial peritonitis. The test, using peritoneal dialysis fluid, was positive for Streptococcus epidermidis . Vancomycin administration led to a good outcome for this patient. The Hybrizep method (which is available on the Japanese National Health system only for the diagnosis of septicemia) was a useful diagnostic approach for a patient on peritoneal dialysis who had peritonitis.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-007-0531-X