Effects of glucocorticoids on polyamine metabolism in liver and spleen of guinea pig during sensitization

Glucocorticoids are potent anti-inflammatory and immunosuppressive agents. As endogenous inhibitors of cytokine synthesis, glucocorticoids suppress immune activation and uncontrolled overproduction of cytokines, preventing tissue injury. Also, polyamine spermine is endogenous inhibitor of cytokine p...

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Bibliographic Details
Published in:Amino acids 2006-11, Vol.31 (4), p.457-462
Main Authors: Bjelakovic, G, Pavlovic, D, Stojanovic, I, Jevtovic, T, Nikolic, J, Kocic, G
Format: Article
Language:English
Subjects:
Animals
Cytokines
Cytokines - immunology
Cytokines - metabolism
Dexamethasone
Dexamethasone - metabolism
Dexamethasone - pharmacology
Freund's Adjuvant
Glucocorticoids
Glucocorticoids - metabolism
Glucocorticoids - pharmacology
Guinea Pigs
Hogs
Immunization
Inhibitors
Liver
Liver - drug effects
Liver - enzymology
Liver - immunology
Liver - metabolism
Male
Metabolism
Oxidase
Oxidoreductases Acting on CH-NH Group Donors - immunology
Oxidoreductases Acting on CH-NH Group Donors - metabolism
Polyamine Oxidase
Polyamines
Polyamines - antagonists & inhibitors
Polyamines - metabolism
Putrescine - metabolism
Serum Albumin, Bovine - immunology
Spermidine - metabolism
Spermine - metabolism
Spleen
Spleen - drug effects
Spleen - enzymology
Spleen - immunology
Spleen - metabolism
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Summary:Glucocorticoids are potent anti-inflammatory and immunosuppressive agents. As endogenous inhibitors of cytokine synthesis, glucocorticoids suppress immune activation and uncontrolled overproduction of cytokines, preventing tissue injury. Also, polyamine spermine is endogenous inhibitor of cytokine production (inhibiting IL-1, IL-6 and TNF synthesis). The idea of our work was to examine dexamethasone effects on the metabolism of polyamines, spermine, spermidine and putrescine and polyamine oxidase activity in liver and spleen during sensitization of guinea pigs. Sensitization was done by application of bovine serum albumin with addition of complete Freund's adjuvant. Our results indicate that polyamine amounts and polyamine oxidase activity increase during immunogenesis in liver and spleen. Dexamethasone application to sensitized and unsensitized guinea pigs causes depletion of polyamines in liver and spleen. Dexamethasone decreases polyamine oxidase activity in liver and spleen of sensitized guinea pigs, increasing at the same time PAO activity in tissues of unsensitized animals.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-005-0286-6