Ex vivo/in vitro absorption of STW 5 (Iberogast ®) and its extract components

To correlate the pharmacological effects of the fixed herbal combination STW 5 (Iberogast ®) containing nine extract components with its confirmed clinical efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2006-01, Vol.13, p.107-113
Main Authors: Kelber, O., Wittwer, A., Lapke, C., Kroll, U., Weiser, D., Okpanyi, S.N., Heilmann, J.
Format: Article
Language:English
Subjects:
Animals
Caco-2
Caco-2 Cells
Carum carvi
Chelidonic acid
Chelidonium majus
Cucurbitacine E
Everted gut sac
Ex vivo/in vitro absorption studies
Gastrointestinal Agents - pharmacokinetics
Glucoiberin
Glycyrhiza glabra
Humans
Iberis amara
In Vitro Techniques
Intestinal Absorption
Intestine, Small - metabolism
Male
Matricaria recutita
Melissa officinalis
Mentha piperita
Pilot Projects
Plant Extracts - pharmacokinetics
Rats
Rats, Sprague-Dawley
Silybum marianum
STW 5 (Iberogast ®)
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Summary:To correlate the pharmacological effects of the fixed herbal combination STW 5 (Iberogast ®) containing nine extract components with its confirmed clinical efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco-2-cell model were used. The absorption rate of the extracts was determined by measuring characteristic marker substances of each of the individual extracts using HPLC or GC techniques. The results allow us to conclude that the investigated substances from STW 5 possess a good bioavailability, which is in accordance with the rapid onset of the therapeutic efficacy and explains its known pharmacological effects and clinical efficacy in terms of multiple drug action and multi-target therapy, respectively.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2006.07.002