Serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy

• Published in: Clinical biochemistry 2007-09, Vol.40 (13), p.1020-1025
• Main Authors: Demirbag, Recep, Yıldız, Ali, Gur, Mustafa, Yilmaz, Remzi, Elçi, Kevser, Aksoy, Nurten
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Dipeptidases - blood; Dipeptidases - metabolism; Female; Humans; Hypertension; Hypertension - blood; Hypertension - metabolism; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - metabolism; Left ventricular hypertrophy; Male; Middle Aged; Prolidase; Spectrophotometry
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2007.05.015

The purpose of this study was to determine serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy. Serum prolidase activity was measured spectrophotometrically in hypertensive patients with (Group II, n = 30) and without left ventricular hypertrophy (Group III, n = 30) and in control group (Group I, n = 30). Prolidase activity was significantly lower in Group I than in Groups II and III (44.64 ± 6.42 U/L vs. 54.14 ± 6.30 U/L and 54.25 ± 7.14 U/L, respectively; ANOVA, p < 0.001). We revealed significant correlation between prolidase activity and presence and duration of hypertension (both of p < 0.05) but not left ventricular mass index. Multivariate analysis shown that prolidase activity was significantly associated with age ( β = 0.481, p < 0.001) and duration of hypertension ( β = 0.396, p < 0.001). Our data show that serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy.