Antimicrobial Susceptibility of Neisseria gonorrheae Strains in Three Regions of Armenia

Objective: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. Methods: Isolates from men with urethral discharge presenting...

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Bibliographic Details
Published in:Sexually transmitted diseases 2007-09, Vol.34 (9), p.686-688
Main Authors: HOVHANNISYAN, GAYANE, VON SCHOEN-ANGERER, TIDO, BABAYAN, KAREN, FENICHIU, OLIVIER, GABOULAUD, VALERIE
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Armenia - epidemiology
Biological and medical sciences
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Drug resistance
Drug therapy
Epidemiology. Vaccinations
General aspects
Gonorrhea
Gonorrhea - drug therapy
Gonorrhea - epidemiology
Gonorrhea - microbiology
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
Kanamycin - administration & dosage
Kanamycin - therapeutic use
Medical sciences
Microbial Sensitivity Tests
Neisseria
Neisseria gonorrhoeae - drug effects
Ofloxacin - pharmacology
Ofloxacin - therapeutic use
Penicillins - pharmacology
Penicillins - therapeutic use
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Summary:Objective: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. Methods: Isolates from men with urethral discharge presenting at 3 STI clinics in 3 different sites of Armenia were used to determine susceptibility of N. gonorrheae strains for 11 antimicrobials using the disc diffusion technique. Results: Among the 101 isolates tested the susceptibility rate for penicillin, doxycycline, and kanamycin were 37.6, 25.7, and 80.2%, respectively. Sensitivity to quinolones was 95% for both ofloxacin and ciprofloxacin. All strains were susceptible to third-generation cephalosporins and to spectinomycin. Only 11% of strains were susceptible to all antibiotics tested. Conclusion: Third-generation cephalosporines and spectinomycin are suitable first-line regimens. Quinolones are not advisable as firstline treatment given current borderline susceptibility, known tendency for rapid resistance development in this class, and frequent over-the-counter use of this antibiotic in Armenia.
ISSN:0148-5717
1537-4521
DOI:10.1097/01.olq.0000258433.36526.b5