Influence of enalapryl on vasomotor reactions of rats with chronic deficiency of dopamine in the mesencephalo-striatal system

The results of experiments on isolated preparations of aorta and portal vein of rats with chronic deficiency of mesencephalo-striatal dopamine have shown that endothelium-dependent reactions of dilatation were inhibited. If rats with dopamine deficiency received enalapryl (20 mg/kg) these reactions...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2007, Vol.53 (3), p.16-22
Main Authors: Talanov, S O, Tkachenko, M M, Baziliuk, O V, Stepanenko, L H, Sahach, V F
Format: Article
Language:Ukrainian
Subjects:
Animals
Aorta, Thoracic - drug effects
Corpus Striatum - metabolism
Disease Models, Animal
Dopamine - deficiency
Enalapril - pharmacology
In Vitro Techniques
Mesencephalon - metabolism
Muscle Contraction - drug effects
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Norepinephrine - pharmacology
Parkinsonian Disorders - metabolism
Parkinsonian Disorders - physiopathology
Rats
Rats, Inbred WKY
Time Factors
Vasoconstrictor Agents - pharmacology
Vasodilation - drug effects
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Summary:The results of experiments on isolated preparations of aorta and portal vein of rats with chronic deficiency of mesencephalo-striatal dopamine have shown that endothelium-dependent reactions of dilatation were inhibited. If rats with dopamine deficiency received enalapryl (20 mg/kg) these reactions partly recovered. A possible conclusion may be that in conditions of cerebral dopamine deficiency the functional state of endothelium got worse, and endothelium-dependent dilatation of vascular smooth muscles was inhibited. The use of inhibitor of angiotensin-converting enzyme enalapryl resulted in a significant restoration of the above vascular reactions.
ISSN:2522-9028