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TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland

Thyroid transcription factor 1 (TTF-1) is required for morphogenesis of the fetal diencephalon. Previous reports showed that mice carrying a TTF-1 null mutation lacked normal development of the pituitary gland. In this study, a role for TTF-1 in the regulation of growth hormone and prolactin transcr...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2007-10, Vol.362 (1), p.193-199
Main Authors: Lee, Nam Oak, Son, Young June, Kim, Jae Geun, Ha, Chang Man, Yun, Chang Ho, Lim, Hye Li, Park, Jeong Woo, D’Elia, Angela Valentina, Damante, Giuseppe, Lee, Byung Ju
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Language:English
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Summary:Thyroid transcription factor 1 (TTF-1) is required for morphogenesis of the fetal diencephalon. Previous reports showed that mice carrying a TTF-1 null mutation lacked normal development of the pituitary gland. In this study, a role for TTF-1 in the regulation of growth hormone and prolactin transcription was identified. In-situ hybridization analysis demonstrated TTF-1 mRNA in the growth hormone-producing cells and prolactin-producing cells of the rat anterior pituitary gland. In the GH3 pituitary cell line, we identified TTF-1 as a factor functionally regulating growth hormone and prolactin transcription. TTF-1 activated prolactin transcription, but inhibited growth hormone transcription. Inhibition and activation of growth hormone and prolactin transcription, respectively, by TTF-1 disappeared upon deletion of the TTF-1 binding motifs within the promoters of these genes. These data suggest that TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2007.08.009