Inherited aspects of papillary thyroid carcinoma

The presence of papillary carcinoma of the thyroid in multiple generations of one kindred is a statistical impossibility as an occurrence of chance. However, traditional and molecular genetic analyses to date have failed to support the notion of a single gene mutation or identify one, in distinct co...

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Bibliographic Details
Published in:Journal of surgical oncology 2006-12, Vol.94 (8), p.719-724
Main Author: Moore Jr, Francis D.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - genetics
Adenomatous Polyposis Coli - genetics
cancer genetics
Carcinoma, Papillary - genetics
Checkpoint Kinase 2
Genes, Tumor Suppressor
Hamartoma Syndrome, Multiple - genetics
Humans
Mutation
Oxyphil Cells - pathology
papillary carcinoma
Protein-Serine-Threonine Kinases - genetics
Proto-Oncogene Proteins c-ret - genetics
Risk Factors
thyroid
thyroid carcinoma
Thyroid Neoplasms - genetics
Thyroiditis, Autoimmune - genetics
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Summary:The presence of papillary carcinoma of the thyroid in multiple generations of one kindred is a statistical impossibility as an occurrence of chance. However, traditional and molecular genetic analyses to date have failed to support the notion of a single gene mutation or identify one, in distinct contrast to medullary carcinoma of the thyroid. Findings to date, outside of distinct multicancer syndromes, suggest the interplay of inherited susceptibility and other factors, such as environmental exposures. It is possible that the main identifiable genetic risk factors at this time are the presence of multinodular goiter or Hashimoto's thyroiditis within the family. J. Surg. Oncol. 2006;94:719–724. © 2006 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.20692