Gene families encoding transcription factors expressed in early development of Strongylocentrotus purpuratus

All genes encoding transcription factors of the bHLH, Nuclear Receptor, Basic Leucine Zipper, T-box, Smad, Sox, and other smaller families were identified in the Strongylocentrotus purpuratus genome by means of a permissive blast search of the genome using a database of known transcription factors....

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Bibliographic Details
Published in:Developmental biology 2006-12, Vol.300 (1), p.90-107
Main Authors: Howard-Ashby, Meredith, Materna, Stefan C., Brown, C. Titus, Chen, Lili, Cameron, R. Andrew, Davidson, Eric H.
Format: Article
Language:English
Subjects:
Animals
Basic zipper
bHLH
Development
Echinoidea
Gene Expression Regulation, Developmental
In Situ Hybridization
Marine
Multigene Family
Nuclear receptor
Phylogeny
Polymerase Chain Reaction
Sea urchin
Sea Urchins - classification
Sea Urchins - genetics
Sea Urchins - growth & development
smad
Sox
Strongylocentrotus purpuratus
Transcription factor
Transcription Factors - genetics
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Summary:All genes encoding transcription factors of the bHLH, Nuclear Receptor, Basic Leucine Zipper, T-box, Smad, Sox, and other smaller families were identified in the Strongylocentrotus purpuratus genome by means of a permissive blast search of the genome using a database of known transcription factors. Phylogenetic trees were constructed for the major families, permitting a comparison of the regulatory protein repertoire of the sea urchin and other species. QPCR and whole mount in situ hybridization experiments revealed the temporal and spatial expression patterns of these genes during early development. These regulatory genes are initially expressed at a broad range of time points, and the large majority of genes of all families are expressed within the first 48 h of development. The observations suggest assignment of many regulatory genes to specific developmental sub-networks, including endomesodermal, oral, aboral, and apical.
ISSN:0012-1606
1095-564X
DOI:10.1016/j.ydbio.2006.08.033