A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study

Sulthiame is a carbonic anhydrase inhibitor that is widely used to treat partial and myoclonic seizures. In 11 healthy adults, we applied transcranial magnetic stimulation (TMS) to the primary motor cortex. Using a cross-over study design, we found that a single oral dose of sulthiame (5 mg/kg) prod...

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Bibliographic Details
Published in:Epilepsy research 2006-11, Vol.72 (1), p.18-24
Main Authors: Siniatchkin, Michael, Groppa, Sergey, Siebner, Hartwig, Stephani, Ulrich
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Anticonvulsants - administration & dosage
Anticonvulsants - pharmacology
Biological and medical sciences
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Cortical excitability
Cross-Over Studies
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Ion channels
Male
Medical sciences
Nervous system
Nervous system (semeiology, syndromes)
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Sulthiame
Thiazines - administration & dosage
Thiazines - pharmacology
Transcranial Magnetic Stimulation
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Summary:Sulthiame is a carbonic anhydrase inhibitor that is widely used to treat partial and myoclonic seizures. In 11 healthy adults, we applied transcranial magnetic stimulation (TMS) to the primary motor cortex. Using a cross-over study design, we found that a single oral dose of sulthiame (5 mg/kg) produced a significant increase of resting motor threshold relative to placebo. No other TMS measure of corticomotor excitability was altered after a single dose of sulthiame. The selective increase in motor threshold suggests that sulthiame produces its antiepileptic effect by reducing the axonal excitability of cortical neurons.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2006.07.001