Elevated Basal Slippage Mutation Rates among the Canidae

The remarkable responsiveness of dog morphology to selection is a testament to the mutability of mammals. The genetic sources of this morphological variation are largely unknown, but some portion is due to tandem repeat length variation in genes involved in development. Previous analysis of tandem r...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of heredity 2007-01, Vol.98 (5), p.452-460
Main Authors: Laidlaw, Jeffrey, Gelfand, Yevgeniy, Ng, Kar-Wai, Garner, Harold R., Ranganathan, Rama, Benson, Gary, Fondon, John W.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Canidae
Canidae - genetics
Carnivora
Carnivora - genetics
Dogs
Dogs - genetics
Evolutionary biology
Genome
Genomics
Humans - genetics
Kinetics
Mice - genetics
Molecular Sequence Data
Mutation
Pan troglodytes - genetics
Repetitive Sequences, Nucleic Acid
Species Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The remarkable responsiveness of dog morphology to selection is a testament to the mutability of mammals. The genetic sources of this morphological variation are largely unknown, but some portion is due to tandem repeat length variation in genes involved in development. Previous analysis of tandem repeats in coding regions of developmental genes revealed fewer interruptions in repeat sequences in dogs than in the orthologous repeats in humans, as well as higher levels of polymorphism, but the fragmentary nature of the available dog genome sequence thwarted attempts to distinguish between locus-specific and genome-wide origins of this disparity. Using whole-genome analyses of the human and recently completed dog genomes, we show that dogs possess a genome-wide increase in the basal germ-line slippage mutation rate. Building on the approach that gave rise to the initial observation in dogs, we sequenced 55 coding repeat regions in 42 species representing 10 major carnivore clades and found that a genome-wide elevated slippage mutation rate is a derived character shared by diverse wild canids, distinguishing them from other Carnivora. A similarly heightened slippage profile was also detected in rodents, another taxon exhibiting high diversity and rapid evolvability. The correlation of enhanced slippage rates with major evolutionary radiations suggests that the possession of a “slippery” genome may bestow on some taxa greater potential for rapid evolutionary change.
ISSN:0022-1503
1465-7333
DOI:10.1093/jhered/esm017