Cardiac [123I]metaiodobenzylguanidine scintigraphy for vascular Parkinsonism

The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of th...

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Bibliographic Details
Published in:Movement disorders 2006-11, Vol.21 (11), p.1990-1994
Main Authors: Kim, Joong-Seok, Lee, Phil-Hyu, Lee, Kwang-Soo, Park, Jeong-Wook, Kim, Yeong-In, Chung, Yong-An, Kim, Sung-Hoon, Kim, Seung-Hyun, Kim, Juhan, Choi, Yun-Young, Kim, Hee-Tae
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - pharmacokinetics
Aged
Aged, 80 and over
Biological and medical sciences
Case-Control Studies
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - drug therapy
Cerebrovascular Disorders - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Heart - diagnostic imaging
Heart - physiopathology
Humans
Male
Medical sciences
MIBG scintigraphy
Middle Aged
Neurology
Parkinson's disease
Parkinsonian Disorders - diagnostic imaging
Parkinsonian Disorders - drug therapy
Parkinsonian Disorders - metabolism
Radionuclide Imaging - methods
Radiopharmaceuticals - pharmacokinetics
Vascular diseases and vascular malformations of the nervous system
vascular Parkinsonism
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Summary:The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 16 age‐matched subjects, and 30 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice. © 2006 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21112