Segmental disorders of the nephron : histopathological and imaging perspective

Recent advances in molecular genetics and immunocytochemistry have clarified the cell of origin in many renal disorders. Several renal disorders are thought to involve specific segments of the nephron. Renin-secreting tumours arise from juxtaglomerular cells. Clear cell and papillary renal cell carc...

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Bibliographic Details
Published in:British journal of radiology 2007-08, Vol.80 (956), p.593-602
Main Authors: PRASAD, S. R, NARRA, V. R, SHAH, R, HUMPHREY, P. A, JAGIRDAR, J, CATENA, J. R, DALRYMPLE, N. C, SIEGEL, C. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - pathology
Humans
Kidney Diseases - diagnostic imaging
Kidney Diseases - pathology
Kidney Glomerulus - pathology
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - pathology
Kidney Tubules - pathology
Kidneys
Magnetic Resonance Imaging
Malformations of the urinary system
Medical sciences
Nephrology. Urinary tract diseases
Nephrons - diagnostic imaging
Nephrons - pathology
Tomography, X-Ray Computed
Tumors of the urinary system
Ultrasonography
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Summary:Recent advances in molecular genetics and immunocytochemistry have clarified the cell of origin in many renal disorders. Several renal disorders are thought to involve specific segments of the nephron. Renin-secreting tumours arise from juxtaglomerular cells. Clear cell and papillary renal cell carcinoma (RCC) recapitulate the epithelium of the proximal tubules. Oncocytoma and chromophobe RCC differentiate towards Type A and Type B intercalated cells of the cortical collecting duct, respectively. Medullary collecting ducts are the target sites for the development of autosomal recessive polycystic kidney disease, collecting duct carcinoma and medullary carcinoma. Renal papillae are susceptible to unique changes such as necrosis or papillitis. The purpose of our article is threefold: to illustrate the imaging findings of renal disorders that show segmental involvement of the nephron, to describe proximal and distal nephron disorders and to correlate imaging findings of some entities with histopathological features.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/20129205