Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality

• Published in: Journal of the American College of Cardiology 2007-09, Vol.50 (10), p.953-960
• Main Authors: Nasir, Khurram, MD, MPH, Shaw, Leslee J., PhD, Liu, Sandy T., MD, Weinstein, Steven R., MD, Mosler, Tristen R., MD, Flores, Phillip R., MD, Flores, Ferdinand R., MD, Raggi, Paolo, MD, Berman, Daniel S., MD, Blumenthal, Roger S., MD, Budoff, Matthew J., MD
• Format: Article
• Language: English
• Subjects: African Americans - statistics & numerical data; Aged; Asian Americans - statistics & numerical data; Calcinosis; Cardiology; Cardiovascular; Cardiovascular disease; Coronary Disease - diagnostic imaging; Coronary Disease - ethnology; Coronary Disease - mortality; Coronary Vessels - chemistry; Coronary Vessels - pathology; European Continental Ancestry Group - statistics & numerical data; Female; Health risk assessment; Heart attacks; Hispanic Americans - statistics & numerical data; Humans; Internal Medicine; Life Expectancy; Male; Middle Aged; Mortality; Prevalence; Prognosis; Proportional Hazards Models; Risk Factors; Studies; Survival Analysis; Tomography, X-Ray Computed; United States - epidemiology
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.03.066

Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality Khurram Nasir, Leslee J. Shaw, Sandy T. Liu, Steven R. Weinstein, Tristen R. Mosler, Phillip R. Flores, Ferdinand R. Flores, Paolo Raggi, Daniel S. Berman, Roger S. Blumenthal, Matthew J. Budoff The aim of the current study was to evaluate the prognostic value of coronary artery calcium (CAC) in a large ethnically diverse cohort of 14,812 patients followed for a mean of 6.8 years (range 0.7 to 14.5 years).When comparing prognosis by CAC scores in ethnic minorities with non-Hispanic whites, relative risk ratios were highest for African Americans with CAC scores ≥400 exceeding 16.1 (p < 0.0001). Hispanics with CAC scores ≥400 had relative risk ratios from 7.9 to 9.0, whereas Asians with CAC scores ≥1,000 had relative risk ratios 6.6-fold higher than non-Hispanic whites (p < 0.0001). Increasing CAC burden was associated with greater mortality in all ethnic/racial groups.