Genomic and non-genomic effects of aldosterone on the individual variation of the sweat Na+ concentration during exercise in trained athletes

• Published in: European journal of applied physiology 2006-11, Vol.98 (5), p.466-471
• Main Authors: Yoshida, Tetsuya, Shin-ya, Hiromi, Nakai, Seiichi, Yorimoto, Akira, Morimoto, Taketoshi, Suyama, Tohru, Sakurai, Masao
• Format: Article
• Language: English
• Subjects: Adult; Aldosterone; Aldosterone - genetics; Aldosterone - metabolism; Blood Proteins - metabolism; Body Temperature - physiology; Cross-Sectional Studies; Exercise - physiology; Genomics; Genotype; Hemoglobins - metabolism; Hot Temperature; Humans; Male; Oxygen Consumption - genetics; Oxygen Consumption - physiology; Physical Fitness - physiology; Plasma Volume - physiology; Rest - physiology; Sodium - metabolism; Sweat; Sweat - metabolism; Sweating - physiology; Variation
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-006-0295-5

To clarify whether the resting background effects (genomic) or exercise-related action (non-genomic) of aldosterone (ALD) is primarily affected to an individual variation in the sweat Na+ concentration ([Na+]sweat), we analyzed the cross-sectional relationship between [Na+]sweat and the plasma ALD concentration during rest and exercise in a hot environment. Eleven college-aged male subjects with a mean maximal oxygen uptake of 48 (range 42-59) ml kg-1 min-1 performed three sessions of 20-min cycle exercise at two levels of intensity (40 or 60% VO2max) in a room maintained at 31 degrees C. The chest sweat rate (SRch) and its containing Na+ were higher and individual differences in SRch and [Na+]sweat were greater at 60% exercise than at 40% exercise. In each individual, the [Na+]sweat increased significantly (P