First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: Clinical and technical aspects of combined therapies

Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symp...

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Bibliographic Details
Published in:European journal of heart failure 2007-09, Vol.9 (9), p.955-958
Main Authors: Butter, Christian, Meyhöfer, Jürgen, Seifert, Martin, Neuss, Michael, Minden, Hans-Heinrich
Format: Article
Language:English
Subjects:
Aged
cardiac contractility modulation
Cardiac Pacing, Artificial - methods
cardiac resynchronization therapy
Combined Modality Therapy
Electrodes, Implanted
heart failure
Heart Failure - therapy
Humans
internal cardiac defibrillator
Male
Myocardial Contraction
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Summary:Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in more than 25% of these CRT patients. CCM may offer a therapeutic option for these non-responders. Here we report the first use of CCM signals in a patient who did not respond to treatment with a CRT-D device. We show that the implantation is technically feasible, that the OPTIMIZER and CRT-D devices can coexist without interference and that acute haemodynamic and clinical improvements can be observed. The results suggest that systematic investigation of CCM treatment in CRT non-responders is warranted.
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2007.05.012