Effectiveness of leukocyte immunotherapy in primary recurrent spontaneous abortion (RSA)

Recurrent spontaneous abortion (RSA) is defined as three or more sequential abortions before the twentieth week of gestation. There are evidences to support an allo-immunologic mechanism for RSA. One of the methods for treatment of RSA is leukocyte therapy; however there is still controversy about e...

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Bibliographic Details
Published in:Iranian journal of immunology 2007-09, Vol.4 (3), p.173-178
Main Authors: Gharesi-Fard, Behrouz, Zolghadri, Jaleh, Foroughinia, Leila, Tavazoo, Fahimeh, Samsami Dehaghani, Alamtaj
Format: Article
Language:English
Subjects:
Abortion, Habitual - immunology
Abortion, Habitual - therapy
Adoptive Transfer
Adult
Case-Control Studies
Female
Humans
Lymphocyte Transfusion
Lymphocytes - immunology
Pregnancy
Pregnancy Outcome
Spouses
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Summary:Recurrent spontaneous abortion (RSA) is defined as three or more sequential abortions before the twentieth week of gestation. There are evidences to support an allo-immunologic mechanism for RSA. One of the methods for treatment of RSA is leukocyte therapy; however there is still controversy about effectiveness of this method. To evaluate the effectiveness of leukocyte therapy for treatment of RSA. Ninety two non-pregnant women with at least three sequential abortions (60 primary & 32 secondary aborters) recognized as RSA were referred to our Laboratory for immunotherapy. All the cases were immunized by isolated lymphocytes from their husbands. Fifty to 100 million washed and resuspended mononuclear cells were injected by I.V., S.C., and I.D. route. The result of each injection was checked by WBC cross matching between couples after four weeks of injections. Immunization was repeated in fifth week to a maximum of 3 times if needed. Eighty one age-matched non-pregnant RSA women (52 primary and 29 secondary aborters) with at least three sequential abortions were also included in this study as controls. The control group was not immunized. 67 out of 92 (72.8%) immunized cases and 44 out of 81 controls (54.3%) showed a successful outcome of pregnancy (p
ISSN:1735-1383