Gender-related differences in the human subthalamic area: a local field potential study

The objective of this study was to investigate the possible existence of gender‐related neurophysiological differences in the oscillatory activity of the human subthalamic area. To this end, we recorded local field potentials (LFPs) after neurosurgical procedures for deep brain stimulation (DBS) in...

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Bibliographic Details
Published in:The European journal of neuroscience 2006-12, Vol.24 (11), p.3213-3222
Main Authors: Marceglia, S., Mrakic-Sposta, S., Foffani, G., Cogiamanian, F., Caputo, E., Egidi, M., Barbieri, S., Priori, A.
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Adult
Aged
Antiparkinson Agents - pharmacology
basal ganglia
Biological Clocks - drug effects
Biological Clocks - physiology
Corpus Striatum - drug effects
Corpus Striatum - physiopathology
Drug Resistance - physiology
electrophysiology
Female
gender
Humans
Levodopa - pharmacology
Male
Middle Aged
Neural Pathways - drug effects
Neural Pathways - physiopathology
Neurons - drug effects
Neurons - physiology
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson's disease
pathophysiology
Sex Characteristics
Subthalamic Nucleus - drug effects
Subthalamic Nucleus - physiopathology
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Summary:The objective of this study was to investigate the possible existence of gender‐related neurophysiological differences in the oscillatory activity of the human subthalamic area. To this end, we recorded local field potentials (LFPs) after neurosurgical procedures for deep brain stimulation (DBS) in 24 patients (12 males and 12 females) with Parkinson's disease. LFP recordings at rest before levodopa medication (19 nuclei from 11 female patients and 16 nuclei from ten male patients) showed significantly higher power in the alpha/low‐beta band (8–12 Hz, P 
ISSN:0953-816X
1460-9568
DOI:10.1111/j.1460-9568.2006.05208.x