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Transoral laser microsurgery for untreated glottic carcinoma
To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma. A 2 center prospective case series analysis. Academic, tertiary referral centers. Seventy-six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%)...
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| Published in: | Otolaryngology-head and neck surgery 2007-09, Vol.137 (3), p.482-486 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4550-43727ad5b4da4fdb1ac715fef1d34fe00df825bf7811e38dc8fd899466f63f753 |
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| cites | cdi_FETCH-LOGICAL-c4550-43727ad5b4da4fdb1ac715fef1d34fe00df825bf7811e38dc8fd899466f63f753 |
| container_end_page | 486 |
| container_issue | 3 |
| container_start_page | 482 |
| container_title | Otolaryngology-head and neck surgery |
| container_volume | 137 |
| creator | Grant, David G. Salassa, John R. Hinni, Michael L. Pearson, Bruce W. Hayden, Richard E. Perry, William C. |
| description | To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma.
A 2 center prospective case series analysis.
Academic, tertiary referral centers.
Seventy-six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%); and T4, 5 (7%). Five (7%) patients had neck dissections. Five (7%) patients received adjuvant radiotherapy. Mean follow-up was 42 months. Respective T1 and T2 5-year Kaplan-Meier estimates were: local control, 90% and 93%; loco-regional control, 90% and 93%; disease specific survival, 90% and 93%; and overall survival, 94% and 93%. The average hospital stay was 2 days. Two (3%) patients experienced major complications. The overall laryngeal preservation rate was 95% (72 of 76).
TLM is a safe and effective treatment in select carcinoma of the glottic larynx. Low morbidity and mortality and short periods of hospitalization make TLM an attractive therapeutic option.
TLM is an emerging strategy in the treatment of laryngeal cancer. |
| doi_str_mv | 10.1016/j.otohns.2007.05.064 |
| format | article |
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A 2 center prospective case series analysis.
Academic, tertiary referral centers.
Seventy-six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%); and T4, 5 (7%). Five (7%) patients had neck dissections. Five (7%) patients received adjuvant radiotherapy. Mean follow-up was 42 months. Respective T1 and T2 5-year Kaplan-Meier estimates were: local control, 90% and 93%; loco-regional control, 90% and 93%; disease specific survival, 90% and 93%; and overall survival, 94% and 93%. The average hospital stay was 2 days. Two (3%) patients experienced major complications. The overall laryngeal preservation rate was 95% (72 of 76).
TLM is a safe and effective treatment in select carcinoma of the glottic larynx. Low morbidity and mortality and short periods of hospitalization make TLM an attractive therapeutic option.
TLM is an emerging strategy in the treatment of laryngeal cancer.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2007.05.064</identifier><identifier>PMID: 17765780</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Cohort Studies ; Databases, Factual ; Female ; Glottis ; Humans ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - surgery ; Laser Therapy ; Male ; Microsurgery ; Middle Aged ; Mouth ; Retrospective Studies ; Treatment Outcome</subject><ispartof>Otolaryngology-head and neck surgery, 2007-09, Vol.137 (3), p.482-486</ispartof><rights>2007 American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2007 SAGE Publications</rights><rights>2007 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4550-43727ad5b4da4fdb1ac715fef1d34fe00df825bf7811e38dc8fd899466f63f753</citedby><cites>FETCH-LOGICAL-c4550-43727ad5b4da4fdb1ac715fef1d34fe00df825bf7811e38dc8fd899466f63f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17765780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grant, David G.</creatorcontrib><creatorcontrib>Salassa, John R.</creatorcontrib><creatorcontrib>Hinni, Michael L.</creatorcontrib><creatorcontrib>Pearson, Bruce W.</creatorcontrib><creatorcontrib>Hayden, Richard E.</creatorcontrib><creatorcontrib>Perry, William C.</creatorcontrib><title>Transoral laser microsurgery for untreated glottic carcinoma</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma.
A 2 center prospective case series analysis.
Academic, tertiary referral centers.
Seventy-six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%); and T4, 5 (7%). Five (7%) patients had neck dissections. Five (7%) patients received adjuvant radiotherapy. Mean follow-up was 42 months. Respective T1 and T2 5-year Kaplan-Meier estimates were: local control, 90% and 93%; loco-regional control, 90% and 93%; disease specific survival, 90% and 93%; and overall survival, 94% and 93%. The average hospital stay was 2 days. Two (3%) patients experienced major complications. The overall laryngeal preservation rate was 95% (72 of 76).
TLM is a safe and effective treatment in select carcinoma of the glottic larynx. Low morbidity and mortality and short periods of hospitalization make TLM an attractive therapeutic option.
TLM is an emerging strategy in the treatment of laryngeal cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Glottis</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Laser Therapy</subject><subject>Male</subject><subject>Microsurgery</subject><subject>Middle Aged</subject><subject>Mouth</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkEtv1DAURi1URKeFf4BQVt0lvU78ilQhwagPpIpuytry2NeDR0lc7KRo_j2ZZiR2hZU33zm6PoR8pFBRoOJyV8Ux_hxyVQPICngFgr0hKwqtLIWi8oSsgLas5G2rTslZzjsAEELKd-SUSim4VLAiV4_JDDkm0xWdyZiKPtgU85S2mPaFj6mYhjGhGdEV2y6OY7CFNcmGIfbmPXnrTZfxw_E9Jz9urh_Xd-X9w-239Zf70jLOoWSNrKVxfMOcYd5tqLGSco-euoZ5BHBe1XzjpaIUG-Ws8k61LRPCi8ZL3pyTi8X7lOKvCfOo-5Atdp0ZME5ZC1U3jEE9D9kyPPwhJ_T6KYXepL2moA_V9E4v1fShmgau52oz9unonzY9ur_QMdM8uFoGv0OH-_-S6oe7719vamhfcLrg2WxR7-KUhjnXv276vDA4h30OmHS2AQeLLiS0o3YxvC74A4qdpBI</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Grant, David G.</creator><creator>Salassa, John R.</creator><creator>Hinni, Michael L.</creator><creator>Pearson, Bruce W.</creator><creator>Hayden, Richard E.</creator><creator>Perry, William C.</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200709</creationdate><title>Transoral laser microsurgery for untreated glottic carcinoma</title><author>Grant, David G. ; Salassa, John R. ; Hinni, Michael L. ; Pearson, Bruce W. ; Hayden, Richard E. ; Perry, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4550-43727ad5b4da4fdb1ac715fef1d34fe00df825bf7811e38dc8fd899466f63f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Glottis</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Laser Therapy</topic><topic>Male</topic><topic>Microsurgery</topic><topic>Middle Aged</topic><topic>Mouth</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grant, David G.</creatorcontrib><creatorcontrib>Salassa, John R.</creatorcontrib><creatorcontrib>Hinni, Michael L.</creatorcontrib><creatorcontrib>Pearson, Bruce W.</creatorcontrib><creatorcontrib>Hayden, Richard E.</creatorcontrib><creatorcontrib>Perry, William C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grant, David G.</au><au>Salassa, John R.</au><au>Hinni, Michael L.</au><au>Pearson, Bruce W.</au><au>Hayden, Richard E.</au><au>Perry, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transoral laser microsurgery for untreated glottic carcinoma</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2007-09</date><risdate>2007</risdate><volume>137</volume><issue>3</issue><spage>482</spage><epage>486</epage><pages>482-486</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma.
A 2 center prospective case series analysis.
Academic, tertiary referral centers.
Seventy-six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%); and T4, 5 (7%). Five (7%) patients had neck dissections. Five (7%) patients received adjuvant radiotherapy. Mean follow-up was 42 months. Respective T1 and T2 5-year Kaplan-Meier estimates were: local control, 90% and 93%; loco-regional control, 90% and 93%; disease specific survival, 90% and 93%; and overall survival, 94% and 93%. The average hospital stay was 2 days. Two (3%) patients experienced major complications. The overall laryngeal preservation rate was 95% (72 of 76).
TLM is a safe and effective treatment in select carcinoma of the glottic larynx. Low morbidity and mortality and short periods of hospitalization make TLM an attractive therapeutic option.
TLM is an emerging strategy in the treatment of laryngeal cancer.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>17765780</pmid><doi>10.1016/j.otohns.2007.05.064</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2007-09, Vol.137 (3), p.482-486 |
| issn | 0194-5998 1097-6817 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Cohort Studies Databases, Factual Female Glottis Humans Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Laser Therapy Male Microsurgery Middle Aged Mouth Retrospective Studies Treatment Outcome |
| title | Transoral laser microsurgery for untreated glottic carcinoma |
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