Vasodilatory effects of cholecystokinin: New role for an old peptide?

Cholecystokinin (CCK) peptides are involved in the control of multiple functions both in the central nervous system (CNS) and in the gastrointestinal tract where they act as neurotransmitters and regulate digestive functions. This review deals with the role of CCK peptides as vasoactive mediators. R...

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Bibliographic Details
Published in:Regulatory peptides 2006-12, Vol.137 (3), p.179-184
Main Authors: Ruiz-Gayo, Mariano, González, M. Carmen, Fernández-Alfonso, Soledad
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Anxiety disorders. Neuroses
Biological and medical sciences
Blood Vessels - innervation
Blood Vessels - physiology
Cerebral blood flow
Cerebrovascular Circulation - physiology
Cholecystokinin
Cholecystokinin - physiology
Fundamental and applied biological sciences. Psychology
Humans
Medical sciences
Migraine
Migraine Disorders - physiopathology
Models, Cardiovascular
Neurology
Nitric oxide
Nitric Oxide - physiology
Panic attack
Panic disorder
Panic Disorder - physiopathology
Postprandial blood flow
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Cholecystokinin - physiology
Splanchnic blood flow
Splanchnic Circulation - physiology
Vascular diseases and vascular malformations of the nervous system
Vasodilation - physiology
Vertebrates: endocrinology
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Summary:Cholecystokinin (CCK) peptides are involved in the control of multiple functions both in the central nervous system (CNS) and in the gastrointestinal tract where they act as neurotransmitters and regulate digestive functions. This review deals with the role of CCK peptides as vasoactive mediators. Recent work from our group demonstrates that CCK peptides induce neurogenic vasodilatation both in cerebral and mesenteric vessels. Such an effect is mediated by nitric oxide and seems to be presynaptic. These findings suggest that endogenous CCK peptides could be relevant vasodilatory agents involved in regulating both cerebral and splanchnic blood flow. We hypothesize here how such an effect could be useful in the interpretation of, in a new conceptual frame, the eventual contribution of CCK to some physiological and physiopathological events, such as splanchnic postprandial hyperaemia, panic attack or migraine.
ISSN:0167-0115
1873-1686
DOI:10.1016/j.regpep.2006.06.006