New antibiotics from bacterial natural products

For the past five decades, the need for new antibiotics has been met largely by semisynthetic tailoring of natural product scaffolds discovered in the middle of the 20 th century. More recently, however, advances in technology have sparked a resurgence in the discovery of natural product antibiotics...

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Bibliographic Details
Published in:Nature biotechnology 2006-12, Vol.24 (12), p.1541-1550
Main Authors: Walsh, Christopher T, Clardy, Jon, Fischbach, Michael A
Format: Article
Language:English
Subjects:
Agriculture
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Antibiotics
Bacteria
Bioinformatics
Biological and medical sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Cyanobacteria
Cyanobacteria - metabolism
DNA, Bacterial
Drug Design
Drug Evaluation, Preclinical
Fundamental and applied biological sciences. Psychology
Genetic Engineering
Genomics
Life Sciences
Nature
Pharmaceutical industry
Pharmacognosy - methods
R&D
Research & development
review-article
Streptomycetaceae - metabolism
Streptomycetes
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Summary:For the past five decades, the need for new antibiotics has been met largely by semisynthetic tailoring of natural product scaffolds discovered in the middle of the 20 th century. More recently, however, advances in technology have sparked a resurgence in the discovery of natural product antibiotics from bacterial sources. In particular, efforts have refocused on finding new antibiotics from old sources (for example, streptomycetes) and new sources (for example, other actinomycetes, cyanobacteria and uncultured bacteria). This has resulted in several newly discovered antibiotics with unique scaffolds and/or novel mechanisms of action, with the potential to form a basis for new antibiotic classes addressing bacterial targets that are currently underexploited.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt1266