Chronic hypergastrinemia : Causes and consequences

The hormone gastrin plays 2 important roles in gastrointestinal physiology--1 as a major factor in meal-stimulated gastric acid secretion and the other as a trophic hormone for epithelial and enterochromaffin cells. These roles are exaggerated to the point of pathology under conditions of chronic hy...

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Bibliographic Details
Published in:Digestive diseases and sciences 2007-10, Vol.52 (10), p.2482-2489
Main Authors: ORLANDO, Lori A, LENARD, Lane, ORLANDO, Roy C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Enzyme Inhibitors - adverse effects
Esophagus
Gastric Acid - secretion
Gastrinoma - blood
Gastrins - blood
Gastrins - drug effects
Gastritis, Atrophic - blood
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Other diseases. Semiology
Peptic Ulcer - drug therapy
Peptic Ulcer - metabolism
Proton Pump Inhibitors
Risk Factors
Zollinger-Ellison Syndrome - blood
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Summary:The hormone gastrin plays 2 important roles in gastrointestinal physiology--1 as a major factor in meal-stimulated gastric acid secretion and the other as a trophic hormone for epithelial and enterochromaffin cells. These roles are exaggerated to the point of pathology under conditions of chronic hypergastrinemia as exemplified by the Zollinger-Ellison syndrome and pernicious anemia. More recently, the concern about the potential risk of chronic hypergastrinemia has risen because of the widespread use of proton pump inhibitors for maintenance therapy in reflux esophagitis. For this reason, we present a concise overview of the origin, causes, and potential risks of chronic hypergastrinemia.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-9419-3