Micronutrients in African-Americans with decompensated and compensated heart failure

Heart failure is thought to be more common and of greater severity in African-Americans (AAs). Potential mechanisms remain uncertain. The importance of micronutrient deficiencies in the pathophysiologic expression of congestive heart failure (CHF) in AAs remains to be explored, including hypovitamin...

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Published in:Translational research : the journal of laboratory and clinical medicine 2006-12, Vol.148 (6), p.301-308
Main Authors: Arroyo, Maximiliano, Laguardia, Stephen P., Bhattacharya, Syamal K., Nelson, Maeda D., Johnson, Patti L., Carbone, Laura D., Newman, Kevin P., Weber, Karl T.
Format: Article
Language:English
Subjects:
Adult
African Americans - statistics & numerical data
Aged
Female
Heart Failure - blood
Heart Failure - ethnology
Heart Failure - physiopathology
Humans
Male
Micronutrients
Middle Aged
Parathyroid Hormone - blood
Selenium - blood
Selenium - deficiency
Vitamin D - analogs & derivatives
Vitamin D - blood
Zinc - blood
Zinc - deficiency
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Summary:Heart failure is thought to be more common and of greater severity in African-Americans (AAs). Potential mechanisms remain uncertain. The importance of micronutrient deficiencies in the pathophysiologic expression of congestive heart failure (CHF) in AAs remains to be explored, including hypovitaminosis D, which can promote secondary hyperparathyroidism (SHPT), together with hypozincemia and hyposelenemia, the 2 most crucial trace minerals integral to diverse biologic functions. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), Zn, and Se were monitored in 30 AAs hospitalized during June through December 2005, with decompensated failure and reduced ejection fraction (EF) (
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2006.08.003