Autoantibodies against Glial Antigens in Paraneoplastic Neurological Diseases

:  Paraneoplastic neurological syndromes are clinically heterogeneous manifestations of cancer, but are not caused by the tumor or its metastases. Because autoantibodies reacting with tumor and nervous system tissue have been described, an autoimmune pathogenesis is suspected. Most autoantibodies ar...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-06, Vol.1107 (1), p.104-110
Main Authors: TSCHERNATSCH, M., GROSS, O., KNEIFEL, N., KRASENBRINK, I., GERRIETS, T., KAPS, M., BLAES, F.
Format: Article
Language:English
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Summary::  Paraneoplastic neurological syndromes are clinically heterogeneous manifestations of cancer, but are not caused by the tumor or its metastases. Because autoantibodies reacting with tumor and nervous system tissue have been described, an autoimmune pathogenesis is suspected. Most autoantibodies are directed against neuronal proteins. Here, we describe the impact of antiglial autoantibodies in paraneoplastic neurological syndromes. Anti‐CRMP5 and antiglial nuclear antibody both can be associated with different paraneoplastic neurological syndromes and tumors.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1381.011