Treatment of cholestatic hepatic diseases: more than the substitution of fat soluble vitamins?

The clinical-biochemical syndrome of cholestasis is characterized by an alteration in bile constituents. As a consequence, the concentrations of bilirubin, bile acids, phospholipids and cholesterol are elevated. The main clinical symptoms of cholestasis are icterus and pruritus, and in severe cases...

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Bibliographic Details
Published in:Der Internist (Berlin) 2006-12, Vol.47 (12), p.1239-1240
Main Authors: Pausch, J, Gatzen, M
Format: Article
Language:ger
Subjects:
Adult
Age Factors
Bile Acids and Salts - metabolism
Bile Duct Neoplasms - etiology
Bile Duct Neoplasms - prevention & control
Cholangiocarcinoma - etiology
Cholangiocarcinoma - prevention & control
Colonic Neoplasms - etiology
Colonic Neoplasms - prevention & control
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Infant
Infant, Newborn
Liver Cirrhosis, Biliary - drug therapy
Liver Cirrhosis, Biliary - etiology
Long-Term Care
Middle Aged
Pregnancy
Risk Factors
Ursodeoxycholic Acid - administration & dosage
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Summary:The clinical-biochemical syndrome of cholestasis is characterized by an alteration in bile constituents. As a consequence, the concentrations of bilirubin, bile acids, phospholipids and cholesterol are elevated. The main clinical symptoms of cholestasis are icterus and pruritus, and in severe cases xanthelasma and xanthoma. Primary intrahepatic cholestasis, caused by impaired bile secretion in the liver, should be separated from the extrahepatic secondary cholestasis which is a consequence of a biliary obstruction. This paper evaluates the therapy of liver diseases which developed as consequence of a primary disturbance in bile secretion.
ISSN:0020-9554
DOI:10.1007/s00108-006-1732-6