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Angiogenic factors for the prediction of preeclampsia in high-risk women

Objective The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. Study Design We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks’ gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and p...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2007-09, Vol.197 (3), p.244.e1-244.e8
Main Authors: Moore Simas, Tiffany A., MD, MPH, Crawford, Sybil L., PhD, Solitro, Matthew J., MD, Frost, Sara C., MD, Meyer, Bruce A., MD, MBA, Maynard, Sharon E., MD
Format: Article
Language:English
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Summary:Objective The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. Study Design We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks’ gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay. Results Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks’ gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk. Conclusions In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.06.030