Mechanisms linking obesity with cardiovascular disease

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure...

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Bibliographic Details
Published in:Nature 2006-12, Vol.444 (7121), p.875-880
Main Authors: Gaal, L.F. van, Mertens, I.L, Block, C.E. de
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity
Blood pressure
Body weight
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - pathology
Cardiovascular Diseases - physiopathology
Coagulation
Diabetes
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Exercise
Health risks
human diseases
Humanities and Social Sciences
Humans
Insulin
Insulin Resistance
Lipids
literature reviews
multidisciplinary
Obesity
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Oxidative Stress
pathophysiology
review-article
Risk factors
Science
Science (multidisciplinary)
Side effects
Smoking
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Summary:Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature05487