The progressive effects of ageing on chemosensitivity in healthy subjects

Summary The aim of this study was to compare the central inspiratory drive (P0.1 ) response to hypoxia and hypercapnia between different age groups of elderly, nonsmoker, healthy subjects and young healthy controls. A random sample, proportionally stratified by age (65–69, 70–74, 75–79 and 80–84 yrs...

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Published in:Respiratory medicine 2007-10, Vol.101 (10), p.2192-2198
Main Authors: García-Río, Francisco, Villamor, Angel, Gómez-Mendieta, Antonia, Lores, Vanesa, Rojo, Blas, Ramírez, Teresa, Villamor, José
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - physiology
Biological and medical sciences
Carbon Dioxide - blood
Carotid bodies
Chemical sensitivity
Chemoreceptor Cells - physiology
Elderly medicine
Female
Forced Expiratory Volume - physiology
Humans
Hypoxic ventilatory responses
Inhalation - physiology
Male
Medical sciences
Oxygen - blood
Pneumology
Pulmonary/Respiratory
Ventilation control
Vital Capacity - physiology
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Summary:Summary The aim of this study was to compare the central inspiratory drive (P0.1 ) response to hypoxia and hypercapnia between different age groups of elderly, nonsmoker, healthy subjects and young healthy controls. A random sample, proportionally stratified by age (65–69, 70–74, 75–79 and 80–84 yrs) from a sample of nonsmoker elderly subjects representative of a general population and 47 healthy subjects aged 20–40 were selected. Arterial blood gas, lung volumes, diffusing capacity, maximal respiratory pressure and oxygen uptake measurements were performed. Breathing pattern and mouth occlusion pressure, as well as P0.1 responses to hyperoxic progressive hypercapnia and isocapnic progressive hypoxia were evaluated. The elderly subjects had lower P0.1 responses to hypoxia (0.017±0.006 vs. 0.031±0.008 kPa/%, P
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2007.04.015