ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide recep...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2006-12, Vol.314 (5806), p.1792-1795
Main Authors: Chen, Yu, Corriden, Ross, Inoue, Yoshiaki, Yip, Linda, Hashiguchi, Naoyuki, Zinkernagel, Annelies, Nizet, Victor, Insel, Paul A, Junger, Wolfgang G
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Adenosine - pharmacology
Adenosine A3 Receptor Agonists
Adenosine A3 Receptor Antagonists
Adenosine triphosphatase
Adenosine Triphosphate - analogs & derivatives
Adenosine Triphosphate - metabolism
Adenosine Triphosphate - pharmacology
Agonists
Animal migration behavior
Animals
Autocrine Communication
Bacteria
Biological and medical sciences
Cell adhesion & migration
Cell Membrane - metabolism
Cell membranes
Cell physiology
Cellular biology
Chemotaxis
Chemotaxis, Leukocyte - drug effects
Cytoplasmic Granules - metabolism
Fundamental and applied biological sciences. Psychology
HL-60 Cells
Humans
Hydrolysis
Leukocytes
Mice
Mice, Knockout
Molecular and cellular biology
Motility and taxis
Neutrophils
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - physiology
Phagocytes
Purinergic P2 Receptor Antagonists
Receptor, Adenosine A3 - metabolism
Receptors
Receptors, Purinergic P2 - metabolism
Receptors, Purinergic P2Y2
Signal amplification
Signal Transduction
Suramin - pharmacology
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Summary:Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors. Neutrophils rapidly hydrolyze released ATP to adenosine that then acts via A3-type adenosine receptors, which are recruited to the leading edge, to promote cell migration. Thus, ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1132559