The Physiology of Phosphoinositides

Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins. Protei...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2007/09/01, Vol.30(9), pp.1599-1604
Main Authors: Sasaki, Takehiko, Sasaki, Junko, Sakai, Takahiro, Takasuga, Shunsuke, Suzuki, Akira
Format: Article
Language:English
Subjects:
Animals
Blood Proteins - physiology
Fab1p-YOPB-Vps27p-EEA1 (FYVE) domain
Humans
lipid kinase
lipid phosphatase
Phosphatidylinositols - genetics
Phosphatidylinositols - metabolism
Phosphatidylinositols - physiology
phosphoinositide
Phosphoproteins - physiology
pleckstrin homology domain
signal transduction
Signal Transduction - physiology
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Summary:Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins. Protein domains that bind phosphoinositides include the pleckstrin homology (PH) domain, the phox homology (PX) domain and the Fab1p-YOPB-Vps27p-EEA1 (FYVE) domain. These domains are found in many proteins involved in intracellular signaling, membrane trafficking and cytoskeletal rearrangement. Recent studies have identified potential links between alterations to various signaling pathways involving phosphoinositides and the etiology of many human diseases.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.1599