Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease

Background New anticoagulants that combine effective anticoagulation with low bleeding rates are still sought after. We investigated the safety, pharmacokinetics, and pharmacodynamics of otamixaban, a direct factor Xa inhibitor, in patients with stable coronary artery disease. Methods This was a ran...

Full description

Saved in:
Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2006-12, Vol.80 (6), p.691-702
Main Authors: Hinder, Markus, Frick, Annke, Jordaan, Pierre, Hesse, Galina, Gebauer, Alexander, Maas, Jochen, Paccaly, Anne
Format: Article
Language:English
Subjects:
Adult
Aged
Area Under Curve
Biological and medical sciences
Cardiology. Vascular system
Comorbidity
Coronary Disease - drug therapy
Coronary Disease - metabolism
Coronary heart disease
Cyclic N-Oxides - pharmacokinetics
Cyclic N-Oxides - pharmacology
Cyclic N-Oxides - therapeutic use
Double-Blind Method
Factor Xa Inhibitors
Female
Heart
Humans
Infusions, Intravenous
International Normalized Ratio
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Pharmacology. Drug treatments
Pyridines - pharmacokinetics
Pyridines - pharmacology
Pyridines - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background New anticoagulants that combine effective anticoagulation with low bleeding rates are still sought after. We investigated the safety, pharmacokinetics, and pharmacodynamics of otamixaban, a direct factor Xa inhibitor, in patients with stable coronary artery disease. Methods This was a randomized, placebo‐controlled, double‐blind, multicenter study in 119 patients with stable coronary artery disease taking maintenance doses of their comedication. Of these patients, 50% had mild renal impairment (creatinine clearance >45 mL/min but
ISSN:0009-9236
1532-6535
DOI:10.1016/j.clpt.2006.09.002